Monday, October 17, 2011

Strengthen Your Immune System & Prevent Disease and Illness

 

 1. Scientifically Proven Unlike most competing products, Protandim has been the focus of several clinical trials and proven to be a super-powerful free-radical fighter. These trials, as well as studies that support its individual ingredients, demonstrate that Protandim is capable of minimizing oxidative stress in the body.

  2. Superior Antioxidant Power Because it stimulates the production of antioxidant enzymes, Protandim delivers exponentially more antioxidant activity than conventional antioxidant vitamins such as vitamin C, E, and betacarotene (a form of Vitamin A). While antioxidant molecules from supplements, foods, and juices can only defeat free radicals on a one-to-one basis (one antioxidant molecule can neutralize only one free-radical molecule) the antioxidant enzymes which Protandim helps your own body produce are catalytic and are NOT used up when they neutralize free radicals.  Therefore, these antioxidants can defeat free radicals many times over.  One antioxidant molecule produced by Protandim can defeat one million free radicals per second 24/7.  No other antioxidant supplement can match Protandim's antioxidant power!

  3. Reduced Oxidative Stress Protandim is the ONLY supplement clinically proven to completely eliminate the age-dependent increase in oxidative stress by reducing oxidative stress levels to those of a 20-year-old in just 30 days.

  4. Enhanced Overall Health Low oxidative stress levels are associated with a healthy cardiovascular system, a healthy brain, proper immune function, and improved overall wellness.

  5. Healthy Immune Support Due to its tremendous production of antioxidant enzymes, Protandim promotes a healthy immune system.

  6. Anti-Aging Ability Protandim is the only supplement in the world clinically proven to reduce cellular aging by an average of 40%.

  7. Increased Glutathione A recent clinical study demonstrated that Protandim produces a 300% increase in glutathione, a key antioxidant and anti-aging compound.

  8. Reduces Inflammation Protandim greatly reduces inflammation, associated with less pain in the body.

  9. One-of-a-Kind

 Protandim, a fundamentally new antioxidant approach in chemoprevention using mouse two-stage skin carcinogenesis as a model.

The Science: Authors
Liu J, et al. Show all

Journal

PLoS One. 2009;4(4):e5284. Epub 2009 Apr 22.

Affiliation

Department of Pharmacology, Toxicology & Neuroscience, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America.

Abstract

Oxidative stress is an important contributor to cancer development. Consistent with that, antioxidant enzymes have been demonstrated to suppress tumorigenesis when being elevated both in vitro and in vivo, making induction of these enzymes a more potent approach for cancer prevention. Protandim, a well-defined combination of widely studied medicinal plants, has been shown to induce superoxide dismutase (SOD) and catalase activities and reduce superoxide generation and lipid peroxidation in healthy human subjects. To investigate whether Protandim can suppress tumor formation by a dietary approach, a two-stage mouse skin carcinogenesis study was performed. At the end of the study, the mice on a Protandim-containing basal diet had similar body weight compared with those on the basal diet, which indicated no overt toxicity by Protandim. After three weeks on the diets, there was a significant increase in the expression levels of SOD and catalase, in addition to the increases in SOD activities. Importantly, at the end of the carcinogenesis study, both skin tumor incidence and multiplicity were reduced in the mice on the Protandim diet by 33% and 57% respectively, compared with those on basal diet. Biochemical and histological studies revealed that the Protandim diet suppressed tumor promoter-induced oxidative stress (evidenced by reduction of protein carbonyl levels), cell proliferation (evidenced by reduction of skin hyperplasia and suppression of PKC/JNK/Jun pathway), and inflammation (evidenced by reduction of ICAM-1/VCAM-1 expression, NF-kappaB binding activity, and nuclear p65/p50 levels). Overall, induction of antioxidant enzymes by Protandim may serve as a practical and potent approach for cancer prevention.

PMID

19384424 [PubMed - indexed for MEDLINE]

PMCID

PMC2668769 Free Full Text
Free full text: Public Library of Science

The chemopreventive effects of Protandim: modulation of p53 mitochondrial translocation and apoptosis during skin carcinogenesis.

Authors

Robbins D, et al. Show all

Journal

PLoS One. 2010 Jul 30;5(7):e11902.

Affiliation

Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America.

Abstract

Protandim, a well defined dietary combination of 5 well-established medicinal plants, is known to induce endogenous antioxidant enzymes, such as manganese superoxide dismutase (MnSOD). Our previous studies have shown through the induction of various antioxidant enzymes, products of oxidative damage can be decreased. In addition, we have shown that tumor multiplicity and incidence can be decreased through the dietary administration of Protandim in the two-stage skin carcinogenesis mouse model. It has been demonstrated that cell proliferation is accommodated by cell death during DMBA/TPA treatment in the two-stage skin carcinogenesis model. Therefore, we investigated the effects of the Protandim diet on apoptosis; and proposed a novel mechanism of chemoprevention utilized by the Protandim dietary combination. Interestingly, Protandim suppressed DMBA/TPA induced cutaneous apoptosis. Recently, more attention has been focused on transcription-independent mechanisms of the tumor suppressor, p53, that mediate apoptosis. It is known that cytoplasmic p53 rapidly translocates to the mitochondria in response to pro-apoptotic stress. Our results showed that Protandim suppressed the mitochondrial translocation of p53 and mitochondrial outer membrane proteins such as Bax. We examined the levels of p53 and MnSOD expression/activity in murine skin JB6 promotion sensitive (P+) and promotion-resistant (P-) epidermal cells. Interestingly, p53 was induced only in P+ cells, not P- cells; whereas MnSOD is highly expressed in P- cells when compared to P+ cells. In addition, wild-type p53 was transfected into JB6 P- cells. We found that the introduction of wild-type p53 promoted transformation in JB6 P- cells. Our results suggest that suppression of p53 and induction of MnSOD may play an important role in the tumor suppressive activity of Protandim.

PMID

20689586 [PubMed - indexed for MEDLINE]

PMCID

PMC2912769 Free Full Text
Free full text: Public Library of Science
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